Our in vitro ADME services are pivotal for early-stage drug discovery, providing critical insights into the absorption, distribution, metabolism, and excretion of compounds. We employ a suite of state-of-the-art technologies and methodologies, including:
Utilizing kinetic and thermodynamic methods, we assess solubility in biorelevant media (FaSGF, FaSSIF, FeSSIF) and PBS, alongside stability studies in fresh plasma, blood, and across various pH levels.
Through PAMPA, Caco-2, and MDCK-MDR1 assays, we evaluate the permeability of drug candidates to predict oral absorption and blood-brain barrier penetration.
Our comprehensive metabolism assessments include metabolic stability in liver microsomes and hepatocytes, Met-ID studies, CYP inhibition and induction profiles, offering deep insights into the metabolic fate of compounds.
We conduct pharmacokinetic studies across a variety of animal models, including mice, rats, beagle dogs, rabbits, hamsters, and monkeys, to understand the absorption, distribution, metabolism and elimination of drug candidates.
Utilizing metabolic cages, we provide detailed analysis on the excretion patterns of compounds, aiding in the understanding of drug clearance mechanisms.
Our tissue distribution studies offer invaluable data on the localization and concentration of compounds within the body, ensuring targeted efficacy and minimized off-target effects.
We conduct a broad range of toxicology tests, including acute and chronic studies, to assess the safety profile of drug candidates.
Our integrated ADME-Tox approach combines pharmacokinetics with toxicity and genotoxicity assessments to ensure that compounds are both effective and safe for clinical use.
3rd Floor, Ventureast Plaza, Financial District, Nanakramguda, Hyderabad, 500032, Telangana, India
Plot No. 9/A Phase III, IDA Jeedimetla, Hyderabad, Telangana 500055, India
Building 900, Synergy square I, Genome valley, Turkapally, Shameerpet, Hyderabad, Telangana 500078, India
533 Airport Boulevard Suite
400, Burlingame, CA 94010
Interested in working with us?
+91 40 6111 6888
Plot No. 9/A Phase III, IDA Jeedimetla, Hyderabad, Telangana 500055, India
3rd Floor, Ventureast Plaza, Financial District, Nanakramguda, Hyderabad, 500032, Telangana, India
Building 900, Synergy square I, Genome valley, Turkapally, Shameerpet, Hyderabad, Telangana 500078, India
533 Airport Boulevard Suite
400,Burlingame, CA 94010
Interested in working with us?
+91 40 6111 6888
