Chemistry

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Chemistry

At LAXAI, we excel in leveraging comprehensive medicinal & synthetic chemistry approaches to drive drug discovery forward. Our team comprises experienced scientists trained at leading institutions worldwide, ensuring the highest quality and innovation in every project. We offer flexible project-specific teams led by dedicated principal scientists, providing innovative solutions to accelerate the programs of our customers. From library synthesis to preclinical Tox-batch, LAXAI delivers excellence in medicinal and synthetic chemistry services.

Medicinal Chemistry

We focus on precise target validation and innovative hit identification, expediting the drug discovery process. Utilizing advanced bioinformatics and structural analysis, we ensure the strength and reliability of target molecules before embarking on hit identification.

Target Validation:

  • Leveraging sophisticated homology modeling and bioinformatics for precise analysis.
  • Thorough identification and refinement of binding sites using advanced structural analysis.
  • Dynamic molecular simulations to accurately predict compound behavior.

Hit Identification:

  • Extensive library enumeration for diverse compound selection.
  • Precision in structure and ligand-based virtual screening.
  • Innovative fragment-based hit identification techniques for novel targets.

Lead Generation

  • Utilizing structure-based design for molecular precision.
  • Utilizing structure-based design for molecular precision.
  • Enhanced e-ADME analysis to predict pharmacokinetics.

Lead Optimization

  • Expert molecular docking for optimal binding
  • 2D and 3D ligand-based design for specificity.
  • Enhanced e-ADME analysis to predict pharmacokinetics.

Medicinal Chemistry

We focus on precise target validation and innovative hit identification, expediting the drug discovery process. Utilizing advanced bioinformatics and structural analysis, we ensure the strength and reliability of target molecules before embarking on hit identification.

Target Validation

Leveraging sophisticated homology modeling and bioinformatics for precise analysis. Thorough identification and refinement of binding sites using advanced structural analysis. Dynamic molecular simulations to accurately predict compound behavior.

Hit Identification

Extensive library enumeration for diverse compound selection. Precision in structure and ligand-based virtual screening. Innovative fragment-based hit identification techniques for novel targets.

lab

Lead Generation

Utilizing structure-based design for molecular precision. 2D and 3D ligand-based design for specificity. Enhanced e-ADME analysis to predict pharmacokinetics.

Lead Optimization

Expert molecular docking for optimal binding. Isostere predictions to refine molecular interactions. Rigorous off-target screening and thorough ADME-Toxicity assessments for safety profiling

Synthetic Chemistry

With over 15 years of domain expertise, we’ve been instrumental in advancing platform technologies for delivering exploratory and intricate chemistries, employing both parallel and conventional methods. Our specialized kilo laboratory and cutting-edge analytical infrastructure facilitate rapid compound production. Backed by a team of over 400 skilled scientists, we offer innovative, cost-efficient, and environmentally friendly solutions.

Our Services

ADCs (Antibody-Drug Conjugates)

We specialize in developing powerful cytotoxic payloads and stable linker chemistries, alongside site-specific conjugation techniques for precise delivery to cancer cells. Our diverse expertise guarantees minimal off-target effects and enhances patient outcomes.

PROTAC (Proteolysis Targeting Chimera)

At the forefront of targeted protein degradation technology, we specialize in designing and synthesizing bifunctional molecules for precise protein modulation. Our innovations are revolutionizing therapeutic approaches for cancer and neurodegenerative diseases.

Nucleosides and Nucleotides

We excel in synthesizing modified nucleosides and nucleotides essential for antiviral drugs, RNA therapeutics, and gene editing tools. Our expertise extends to optimizing synthetic pathways to yield high-quality building blocks.

Peptides

We specialize in designing, synthesizing, and modifying peptides for therapeutic use. Our expertise includes employing conjugation strategies to improve stability, enhance bioavailability, and enable targeted delivery.

Carbohydrates

Carbohydrates

We specialize in synthesizing complex carbohydrates and glycoconjugates with unique properties tailored for specific targeting and modulation of immune responses.

Lipids

Well-versed in synthesizing and characterizing lipids essential for mRNA vaccine delivery and gene therapy.

Carbocyclic Chemistry

Pioneered in synthesizing complex heterocyclic molecules for pharmaceutical applications, with expertise in constructing carbocyclic frameworks to enhance efficacy.

Asymmetric Synthesis

Specialist in chiral synthesis using advanced organometallic techniques.

Scaffolds & Building Blocks Synthesis

Design and synthesis of complex molecular scaffolds and building blocks. Facilitation of novel routes for rapid library construction.

Infrastructure and Instrumentation

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Let's begin the conversation

Address

Corporate Office

3rd Floor, Ventureast Plaza, Financial District, Nanakramguda, Hyderabad, 500032, Telangana, India

GMP Manufacturing Site

Plot No. 9/A Phase III, IDA Jeedimetla, Hyderabad, Telangana 500055, India

Discovery Centre

Building 900, Synergy square I, Genome valley, Turkapally, Shameerpet, Hyderabad, Telangana 500078, India

US Office

533 Airport Boulevard Suite
400, Burlingame, CA 94010

Pages

Business

Work inquiries

Interested in working with us?

bd@laxai.com

Any question call

+91 40 6111 6888

Address

GMP Manufacturing Site

Plot No. 9/A Phase III, IDA Jeedimetla, Hyderabad, Telangana 500055, India

Corporate Office

3rd Floor, Ventureast Plaza, Financial District, Nanakramguda, Hyderabad, 500032, Telangana, India

Discovery Centre

Building 900, Synergy square I, Genome valley, Turkapally, Shameerpet, Hyderabad, Telangana 500078, India

US Office

533 Airport Boulevard Suite
400,Burlingame, CA 94010

Pages

Business

Work inquiries

Interested in working with us?

bd@laxai.com

Any question call

+91 40 6111 6888