DMPK and Tox studies

We provide an extensive and adaptable selection of in vitro and in vivo DMPK studies that cover a broad range of activities from hit-to-lead and lead optimization phases to candidate selection and subsequently perform the studies to support up to IND filing.

Understanding the intricacies of how compounds interact with biological systems is at the heart of developing therapies that are not only effective but also safe. Our DMPK and TOX studies are meticulously designed to navigate the complex landscape of drug metabolism, pharmacokinetics, and safety assessments, ensuring your drug candidates are optimized for success from the early stages of drug discovery to the final steps before clinical trials.

Highlights

Fast turnaround times for in-vitro and in-vivo studies.
Sciex 4500 QTrap equipped with LightSight software, for soft spot metabolite identification.
Expert scientific interpretations that will enable to advance your drug development programs.
Support for structure-activity relationship (SAR) modifications within integrated drug discovery programs.

In-Vitro ADME Studies

Our in vitro ADME services are pivotal for early-stage drug discovery, providing critical insights into the absorption, distribution, metabolism, and excretion of compounds. We employ a suite of state-of-the-art technologies and methodologies, including:

Physicochemical Screening

Utilizing kinetic and thermodynamic methods, we assess solubility in biorelevant media (FaSGF, FaSSIF, FeSSIF) and PBS, alongside stability studies in fresh plasma, blood, and across various pH levels.

Permeability Assays

Through PAMPA, Caco-2, and MDCK-MDR1 assays, we evaluate the permeability of drug candidates to predict oral absorption and blood-brain barrier penetration.

Metabolism Studies

Our comprehensive metabolism assessments include metabolic stability in liver microsomes and hepatocytes, Met-ID studies, CYP inhibition and induction profiles, offering deep insights into the metabolic fate of compounds.

In-Vivo Studies

The transition from in-vitro assessments to in-vivo studies is a critical step in drug development. Our in-vivo services encompass

Pharmacokinetics

We conduct pharmacokinetic studies across a variety of animal models, including mice, rats, beagle dogs, rabbits, hamsters, and monkeys, to understand the absorption, distribution, metabolism and elimination of drug candidates.

Excretion Studies

Utilizing metabolic cages, we provide detailed analysis on the excretion patterns of compounds, aiding in the understanding of drug clearance mechanisms.

Distribution Assessments

Our tissue distribution studies offer invaluable data on the localization and concentration of compounds within the body, ensuring targeted efficacy and minimized off-target effects.

Safety Assessment

Safety is paramount in drug development. Our TOX studies are designed to identify potential toxicities early in the development process

Toxicology Testing

We conduct a broad range of toxicology tests, including acute and chronic studies, to assess the safety profile of drug candidates.

ADME-Tox Integration

Our integrated ADME-Tox approach combines pharmacokinetics with toxicity and genotoxicity assessments to ensure that compounds are both effective and safe for clinical use.